Manganese inhalation by welders can produce the clinical symptoms described. Neuronal loss can be found in several areas of the brain including the globus pallidus, hypothalamus, cerebellum, and caudate. The treatment of choice is L-dopa and chelation with EDTA, however the efficacy of each is limited and the benefit is typically transient. Another toxin that can cause Parkinsonism is MPTP. MRI Brian in manganese toxicity would show hyperintensity of the bilateral globus pallidi.