MG = post-synaptic disease that worsens with exertion
– associated with thymomas
– Symptomatic Tx: pyridostigmine
LEMs = presynaptic disease that improves with exertion
– associated with malignancy, most commonly small cell lung cancer (SCLC)
– Symptomatic Tx: 3,4 DAP
MG tested with 2-3 Hz repetitive stimulation, while LEMS can be tested with 50Hz repetitive stimulation (which is asked on exams but rarely used clinically because its very uncomfortable for patients)