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Which of the following is the mechanism of action of entacapone?
An 8-year-old girl presents with a progressive neurologic disorder. She initially was noted to have slow learning and clumsiness years ago. Shortly thereafter she developed a seizure disorder of unclear etiology. Now, she has been having progressive visual changes and worsened cognition and memory. To aid in the diagnosis, a muscle biopsy is done and shows autofluorescent curvilinear bodies. Her disorder falls into which category of disease?
A 38-year-old man with long-standing migraines was recently hospitalized for an unprovoked seizure. Upon further questioning, the patient admits to a strong family history of headaches and early strokes. A brain MRI is completed and a T2 sequence image is shown below. This patient likely has a mutation in which of the following genes?
An 18-year-old male with a history of IV drug use was found unresponsive on a park bench by police. He was intubated by EMS and sent directly to the emergency room. The patient is comatose on examination. CT scan of the head is shown below. What is the likely diagnosis?
Aquaporin-4 (AQP4) channels are found on which cell type?
A 45-year-old female presents as a trauma for an unhelmeted motorcycle accident. She has sustained significant blunt head trauma, and CTH shows hydrocephalus caused by edematous mass effect compressing the fourth ventricle. Which of the following shows the correct directional flow of CSF in a normal individual?
What is the mechanism of action of phenobarbital?
Which of the following medications is the most appropriate pharmacologic agent for paroxysmal kinesigenic dyskinesia?
A 63-year-old woman with a history of right-sided breast cancer status post-mastectomy, chemotherapy, and radiation presents to your clinic with a 2 months history of right arm pain and paresthesias. Which of the following findings on EMG/NCS would most likely suggest a radiation-induced plexopathy over a recurrent neoplastic plexopathy?
A 60-year-old woman with a history of diabetes is presenting to the neurology clinic with a 4-month history of burning/tingling in her bilateral toes. Neurological examination revealed 5/5 strength in all muscle groups, normal reflexes, and intact sensation to light touch in the bilateral lower extremities. There was mildly decreased sensation to pinprick in the 1st toe bilaterally. Which of the following tests is the most likely to be diagnostic for this patient?
A 35-year-old woman presents to the clinic with headaches. Her past medical history is significant for migraines and a sprained ankle four months ago that she has been managing with daily NSAIDs. Her headaches started a month ago and have been occurring every day for the past three weeks. She describes the headaches as a band-like pressure around her head. Nothing has helped but the symptoms are worse in the mornings. A recent brain MRI was completed during an emergency room visit which was unremarkable. Which of the following is the most appropriate next step in therapy?
Which of the following symptoms seen with normal pressure hydrocephalus (NPH) is the most responsive CSF shunt placement?
A 52-year-old woman is brought to the emergency room in respiratory distress. She is accompanied by her husband who stated that they were eating at a high-end sushi restaurant when his wife started to complain of perioral numbness and tingling. Two hours later she started to complain of generalized weakness and trouble breathing. Accidental poisoning is suspected. Based on the available information, what is the mechanism of action of the poison ingested?
Anti-GQ1b antibodies are associated with which syndrome?
The pathology shown in the image below is likely secondary to which of the following?