Quiz 07/24/2022 (7)

This muscle biopsy is most consistent with which myopathic disease?

Which of the following medications, when taken alongside statin therapy, increases the risk of statin-induced myopathy?

A 47-year-old female presents to the clinic with the chief complaint of slowly progressive proximal muscle weakness. Electromyography showed short duration, low amplitude motor unit action potentials. A muscle biopsy was performed and shown below. A diagnosis is made and the patient is started on a therapeutic agent. What is the most likely medication initiated?

Which of the following is the most classic finding of early inclusion body myositis?

Which of the following medications is effective in the treatment of myotonia?

A 47-year-old female presents to the clinic with the chief complaint of slowly progressive proximal muscle weakness. Electromyography showed short duration, low amplitude motor unit action potentials. A muscle biopsy was performed and shown below. A diagnosis is made and the patient is started on a therapeutic agent. What is the most likely medication initiated?

A 65-year-old man comes to the clinic with a one-year history of difficulty walking. More recently, he has also noticed a tendency to drop things. On examination, he was found to have weakness in his bilateral lower limbs, predominantly in his quadriceps muscles, along with finger flexion weakness that is worse on the left side. His sensory examination was normal. Which of the following is the most likely diagnosis?

A 5-year-old male presents because of muscle stiffness. His symptoms are worse during the colder winter months and with gym class at school. He sometimes becomes so stiff he can hardly breathe. Examination shows no muscle atrophy or hypertrophy but myotonia is present. Upon further questioning, you learn he has an older brother with similar symptoms. What is the likely dysfunctional gene in this patient?

This muscle biopsy is most consistent with which myopathic disease?

Which of the following is seen on muscle biopsy in patients with steroid myopathy?

A 57-year-old male with recently diagnosed small cell lung cancer (SCLC) is presenting to the electromyography lab with a one-month history of muscle cramps and muscle pain. Percussive myotonia is appreciated on examination. Electromyography showed myokymic discharges. Autoantibodies against which of the following channels are likely present in this case?

This muscle biopsy is most consistent with which myopathic disease? 

Eteplirsen is an effective treatment in patients with Duchenne muscular dystrophy (DMD) that have which of the following dystrophin mutations?

A 27-year-old female with a history of cataracts and an unknown family history was referred to the neurology clinic for excessive daytime sleepiness. On examination facial weakness and grip myotonia were appreciated. Genetic testing revealed a mutation in the DMPK gene. Based on her diagnosis, which of the following tests should be performed annually?

A four-year-old boy with no significant past medical history is brought to your clinic due to difficulty walking. His mother states that he began walking at 12 months of age, but in the past few months, he seems to be more fatigued and weak when walking. On physical exam, his calves seem to be abnormally large. This disorder is caused by what mutation?