Demyelinating Disease Flashcards

Welcome to our Neurology Flashcards! Understanding is paramount, but unfortunately, one aspect of academic success does rely on simple memorization and repetition. We have taken the most commonly seen rote memory topics and “buzzwords” from neurology board and RITE* exams and made easy-to-use flashcards. These work on desktop, tablet, and mobile devices.

Decreased visual acuity, color vision loss, eye pain, & afferent pupillary defect
Optic neuritis
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Dimethyl fumarate
Mechanism of action
Reduces toxic oxidative stress through activation of the nuclear 1 factor (erythroid-derived 2)-like 2 (Nrf2) antioxidant response pathway.
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Anti-aquaporin-4 (AQP4)
Neuromyelitis Optica (NMO)
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Fingolimod
Sequesters lymphocytes in lymph nodes, thereby reducing the number of lymphocytes in peripheral circulation and the central nervous system. This is performed by downregulating sphingosine-1-phosphate receptors (S1PR) expressed on lymphocytes in secondary lymphoid tissue.
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McDonald Criteria: Lab finding that substitutes as a "Dissemination in Time" criterion.
(According to the most recent (2017) revision)
Oligoclonal bands in the CSF
(Serum oligoclonal bands do not count)
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McDonald Criteria Requirements
(According to the most recent (2017) revision)
To make a diagnosis of relapsing multiple sclerosis, you need at least TWO "Dissemination in Space" criteria and TWO "Dissemination in Time" criteria.
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