Below you will find over 200 high-yield neuropathology slides and images. These images were selected to be the most valuable for in-service/RITE* and ABPN board examinations.
![CIDP with Onion Bulbs Nerve biopsy of a patient with CIDP showing onion bulb pathology](https://www.nowyouknowneuro.com/wp-content/uploads/cache/CIDP/4201751469.jpg)
CIDP with Onion Bulbs
Toluidine blue (Left) and trichrome (right) stains of a peripheral nerve showing very large onion bulbs surrounding small thinly-myelinated nerve fibers secondary to repeated cycles of demyelination and re-myelination. This can be appreciated in hereditary demyelinating neuropathies.
![Sarcoidosis of Muscle A skeletal muscle biopsy H&E stain with a non-caseating granuloma and a multinucleated giant cell of sarcoidosis](https://www.nowyouknowneuro.com/wp-content/uploads/cache/Sarcoidosis-of-muscle/3039074269.jpg)
Sarcoidosis of Muscle
A skeletal muscle biopsy H&E stain with a non-caseating granuloma and a multinucleated giant cell.
![Normal Oligodendrocyte Normal Oligodendrocyte on pathology stain](https://www.nowyouknowneuro.com/wp-content/uploads/cache/Normal-oligodendrocyte/3471004066.jpg)
Normal Oligodendrocyte
Oligodendrocyte nuclei can be seen in white matter, often in short chains, and have smaller more dense nuclei than astrocytes.
![Spongiform Encephalopathy (CJD) H&E stain showing many small round vacuoles consistent with spongiform encephalopathy.](https://www.nowyouknowneuro.com/wp-content/uploads/cache/CJD-micro-3/481944677.jpg)
Spongiform Encephalopathy (CJD)
H&E stain showing many small round vacuoles consistent with spongiform encephalopathy.
![Polymyositis Polymyositis Muscle Biopsy slide for Neurology Board and RITE Practice Question Question Bank](https://www.nowyouknowneuro.com/wp-content/uploads/cache/Muscle-biopsy-with-inflammatory-cells-in-the-endomysium-between-and-around-individual-myofibers_-/1156130072.jpg)
Polymyositis
Muscle biopsy with inflammatory cells in the endomysium (between and around individual myofibers) consistent with polymyositis.
![Periventricular Leukomalacia Periventricular Leukomalacia neuropathology slide of Very low power view poorly stained H&E with chalky white periventricular white matter lesions with necrosis](https://www.nowyouknowneuro.com/wp-content/uploads/cache/periventricular_leukomalacia_hande/369166265.jpg)
Periventricular Leukomalacia
Very low power view poorly-stained H&E with chalky white periventricular white matter lesions with necrosis.
![Craniopharyngioma Craniopharyngioma pathology specimen showing Encapsulated tumor with well differentiated nonkeratinizing squamous epithelium and papillary fibrovascular stroma](https://www.nowyouknowneuro.com/wp-content/uploads/cache/craniopharyngioma_encapsulated_nonkeratin_papillary/874152821.jpg)
Craniopharyngioma
Encapsulated tumor with well-differentiated non-keratinizing squamous epithelium and papillary fibrovascular stroma.
![Acute Disseminated Encephalomyelitis Acute Disseminated Encephalomyelitis Biopsy with perivenous infiltration of lymphocytes and demyelination](https://www.nowyouknowneuro.com/wp-content/uploads/cache/adem_perivenous_lymphocytes_demyelination/512840541.jpg)
Acute Disseminated Encephalomyelitis
Biopsy with perivenous infiltration of lymphocytes and demyelination.
![HIV Brain Biopsy Neuroinfectious disease HIV Brain Biopsy pathology slide with perivascular macrophages and multinucleate giant cells in white matter](https://www.nowyouknowneuro.com/wp-content/uploads/cache/hiv_perivascular_multinucleate_giantcells/2813903580.jpg)
HIV Brain Biopsy
Brian biopsy with perivascular macrophages and multinucleate giant cells in white matter.
![Lacunar Stroke in the Putamen Lacunar Stroke in Right Putamen on coronal gross brain pathology specimen](https://www.nowyouknowneuro.com/wp-content/uploads/cache/putamen_lacunar_stroke/1739311065.jpg)
Lacunar Stroke in the Putamen
Note the small lake-like vacuous space within the putamen on the left side of this image.
![Glioblastoma Multiforme Glioblastoma Multiforme coronal gross brain section showing Large necrotic mass with increased vascularity and mass effect on the surrounding white matter](https://www.nowyouknowneuro.com/wp-content/uploads/cache/gbm_necrosis_high_vascularity/2247034758.jpg)
Glioblastoma Multiforme
Coronal gross cut. Large necrotic mass with increased vascularity and mass effect on the surrounding white matter.
![Medulloblastoma Cerebellar Medulloblastoma gross pathology specimen](https://www.nowyouknowneuro.com/wp-content/uploads/cache/cerebellar_medulloblastoma/3056550650.jpg)
Medulloblastoma
Cerebellar mass with mass effect into the 4th ventricle consistent with a medulloblastoma.
![Multiple Sclerosis Plaque Multiple Sclerosis Plaque on gross brain specimen](https://www.nowyouknowneuro.com/wp-content/uploads/cache/ms_plaque/2572776060.jpg)
Multiple Sclerosis Plaque
Note the well-demarcated periventricular tan-gray patches of demyelination (arrow).