Dementia and neurodegeneration are high yield topics for the RITE®, board, and shelf examinations. In particular, understanding the different tauopathies, like Alzheimer’s disease, and alpha-synucleinopathies, like Lewy body dementia, will get you very far on these exams. In this chapter, you will find the high-yield topics you need to learn, including classic pathology slides and radiographic images you may see on exam day. Learn this knowledge well, then test what you have learned with a practice quiz at the end!
Authors: Daniel Varon MD, Brian Hanrahan MD
Chapter Multimedia Content
Table of Contents
Types of Memory
- Associated with implicit memory of how to perform certain tasks such as tying shoes or riding a bike.
- Damage to the basal ganglia and cerebellum can lead to procedural memory problems.
- Memory that is specific to autobiographical events (i.e. times, names, and places).
- Deficits localize to the Papez circuit (hippocampus, fornix, mammillary bodies, anterior thalamus, cingulate, entorhinal cortex)
- Deficits in episodic memory are typical of Alzheimer’s disease (AD).
- Also considered “short term memory”, it is the cognitive system responsible for storing temporary pieces of information.
- Phonologic working memory involves the prefrontal cortex, Broca’s, and Wernicke’s areas. An example is remembering a phone number “in your head” before dialing.
- Spatial working memory Involves the prefrontal cortex and visual associated areas. An example is following a route to the end of a maze.
- Semantic memories do not tend to come from personal experience.
- Deficits of semantic memory lead to the loss of “common knowledge” things such as names of colors, and other basic life facts.
- Semantic deficits may be related to the temporal lobe pathology, specifically the inferior temporal cortex.
Types of Neurocognitive Testing
- Stroop test: Subjects are presented with names of colors written in colors other than the one spelled out (i.e. the word “red” written in green ink) and are then asked to repeat the color of the word back to the examiner. This is a test used specifically to evaluate executive function, most specifically attention.
- Digit span test: Subjects are read or asked to read a sequence of numbers and then recall them in the same order. This test is used to analyze working memory.
- Wisconsin Card Sorting Test: Assesses visual conceptualization and set-shifting which may be deficient in prefrontal cortex lesions.
- California Verbal Learning Test: In this test of episodic memory, subjects are read a list of 16 nouns out loud five times and after each trial, the subject is asked to recall as many as they can in order.
- The Trail Making Test: Used to evaluate executive functioning, speed of processing, and mental flexibility.
- The Wechsler Adult Memory Scale (WAIS-IV): A comprehensive cognitive test that evaluates a subject’s verbal comprehension, perceptual reasoning, working memory, and processing speed.
- The Boston Naming Test: Examiners go through several images individually and ask the subject to identify the word. Those with aphasia or other language disturbances will struggle with this test as it evaluates confrontational word retrieval.
- Clock-Drawing Test: Evaluates visuospatial function, attention, and executive function.
- Go/no-go Test: Patients are instructed to tap once in response to a single tap by the examiner and to withhold a response for two taps. Assesses for disinhibition and frontal lobe dysfunction.
Mild Cognitive Impairment (MCI)
- Felt to be a precursor to Alzheimer’s disease among other neurodegenerative diseases (FTD, LBD, etc.).
- Progresses to dementia at a rate of 10-15% per year.
- Presents with subjective memory complaint while still having objective normal cognition and no limitations in normal activities of daily living.
- Imaging can show early mesial temporal/hippocampal volume loss on MRI.
- Function: Assists in microtubule function as a microtubular associated protein.
- Genetics: encoded by microtubule-associated protein tau (MAPT) gene
- Pathology: Cell death leads to leakage of cellular contents leading to elevated levels of tau and formation of neurofibrillary tangles which are immunoreactive for phosphorylated tau.
Alzheimer’s disease (AD)
- Presents with impairment of memory and at least one other area of cognition.
- Early symptoms include forgetfulness for recent events or newly acquired information, disorientation, and difficulty with complex cognitive functions.
- The degree of memory loss usually correlates with the severity of the loss of cholinergic neurons in the nucleus basalis of Meynert, which has cholinergic projections to the cerebral cortex.
- Posterior cortical atrophy is a rare, visual variant of AD which presents with a relatively selective decline in visual processing skills, leading to difficult reading, identifying objects, etc.
- Early-onset genes
- Presenilin 1:
- Most common single-gene cause of AD. It is autosomal dominant with 100% penetrance and located on chromosome 14.
- Assists gamma-secretase in cleaving amyloid precursor protein. When the gene is pathologic it leads to abnormal cleaving and plaque formation.
- Presenilin 2:
- Located on chromosome 1.
- Amyloid precursor protein (APP):
- Located on chromosome 21.
- People with Down syndrome (trisomy 21) have a higher risk of Alzheimer’s disease due to the overproduction of APP.
- Presenilin 1:
- Apolipoprotein E (APOE) gene:
- Susceptibility gene found on chromosome 19.
- Works by assisting the metabolism and transport of β-amyloid.
- APOE 4 allele increases risk by 5-15 fold.
- APOE 2 allele decreases the risk of AD.
- Used to help predict conversion from MCI to AD.
- CSF studies: Can be more sensitive than cognitive testing to predict conversion to AD from MCI.
- Elevated total and phosphorylated tau levels due to dying and damaged neurons
- Decreased beta-amyloid 1-42 due to an accumulation of amyloid in plaques.
- Microscopic analysis will show extracellular amyloid neuritic plaques and dystrophic neurites with reactive astrocytes and microglia.
- Intracellular neurofibrillary tangles, Hirano bodies, neuronal granulovacuolar degeneration, and the deposition of amyloid in the walls of blood vessels can also be seen.
- Neurofibrillary tangles: Flame-shaped intracellular inclusion bodies of phosphorylated tau protein.
- Hirano bodies: Intracellular aggregates of actin and actin-associated proteins, which are not specific to Alzheimer’s disease.
- Granulovacuolar degeneration: Intraneuronal accumulation of large (up to 5 µm diameter) double membrane-bound vacuoles harboring a central granule.
- Widening of the cortical sulci and enlargement of the lateral ventricles
- Microhemorrhages secondary to amyloid angiopathy can also occur in cortical and subcortical locations.
- Hippocampal and high parietal atrophy
- Fluorodeoxyglucose (FDG) PET imaging:
- The study is performed with an injection of a short-lived radioactive form of sugar in order to show activity levels in various parts of the brain.
- In MCI, hypometabolism is seen in the medial portion of the parietal cortex and the posterior cingulate gyrus.
- For AD, hypometabolism involves a larger region of the posterior cingulate gyrus than MCI. It also involves the temporal and parietal cortices.
- Beta-amyloid PET:
- Binds to beta-amyloid thereby tracking amyloid-beta protein load.
- Can be used to determine the risk of developing Alzheimer’s disease in asymptomatic individuals.