Welcome to our new feature: NEUROLOGY FLASHCARDS! Understanding is paramount, but unfortunately, one aspect of academic success does rely on simple memorization and repetition. In our new Neurology flashcards feature, we have taken the most commonly seen rote memory topics and “buzzwords” from neurology board and RITE* exams and made easy to use flashcards. These work on desktop, tablet, and mobile devices. This is a new feature, so please contact us if you see any issues! FLASHCARDS will be available for all chapters soon!

Dermatomyositis antibody associated with highest cancer risk
Anti-TIFγ
Both polymyositis and dermatomyositis (DM) have cancer risk, but risk is higher with DM, especially when anti-TIFγ is present (5-fold increase, usually breast).
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Weakness in finger flexors and quadriceps
Inclusion body myositis (IBM)
Usually a male > age 50. This is the classic exam question presentation.
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Endomysial and perivascular muscle inflammation
(Inflammatory cells surround individual muscle fibers)
Polymyositis
Note the inflammatory cells around each FIBER.
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Perifascicular muscle inflammation
(Inflammatory cells around muscle fascicles. A fascicle is a group of muscle fibers)
Dermatomyositis
Note inflammatory cells surround the entire fascicle, not each fiber.
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Antibody associated with inclusion body myositis (IBM)
Anti-cytoplasmic 5′-nucleotidase 1A (cN1A; NT5C1A)
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Antibodies associated with immune-mediated necrotizing myopathy
Name 2
Anti-SRP and anti-HMG-CoA reductase
SRP = signal recognition protein
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Emery-Dreifuss muscular dystrophy mutations
EMD & FLH1 are X-linked, while LMNA is usually autosomal dominant.
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Mutations in:
Type 1 Myotonic Dystrophy:
Type 2 Myotonic Dystrophy:
Type 1 Myotonic Dystrophy: Autosomal dominant CTG repeat in DMPK gene.
Type 2 Myotonic Dystrophy: Autosomal dominant CCTG (tetranucleotide repeat) in CNBP gene.
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Dantrolene
Mechanism of action
Malignant hyperthermia treatment
Prevents release of calcium from sarcoplasmic reticiculum, perhaps by binding to RYR1 receptor.
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Attacks of weakness, muscle pain, and myoglobinuria with exercise
Carnitine palmitoyltransferase (CPT) Deficiency
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