silver-stained slide is showing a flame-shaped intracellular inclusion of phosphorylated tau protein called a neurofibrillary tangle. These lesions are seen in tauopathies like Alzheimer’s disease. Amyloid plaques and Hirano bodies can also be seen in Alzheimer’s disease however amyloid plaques are extracellular exclusions. Hirano bodies are a non-specific indication of neurodegenerative disease