Quiz 06/11/2022 (1)

Which of the following comorbidities would prohibit the use of dalfampridine?

A 38-year-old female presents to the clinic with episodes of facial pain. She reports episodes of sudden severe and debilitating sharp pain on her right face lasting a few seconds to a couple of minutes. These seem to be triggered by eating or lightly touching the face. Outside of these episodes, she is pain-free. She does not endorse any associated rhinorrhea, lacrimation, or facial flushing. What is the likely cause of her symptoms?

The lesion shown below is most consistent with which of the following pathologies?

Which of the following is the mechanism of action for natalizumab?

Which of the following is a common side effect of dimethyl fumarate?

A 50-year-old male presents to the emergency room with a three-day history of double vision and difficulty walking. Neurological examination reveals decreased eye movements. Strength in the limbs is relatively preserved but all reflexes are absent. There is also marked limb clumsiness. Which of the following is the most likely diagnosis?

Which of the following testing can be used to diagnose a small fiber neuropathy?

A patient with relapsing-remitting multiple sclerosis presents to the emergency department with a new headache, confusion, and vision loss. A T2 sequence from their MRI is shown below. Lumbar puncture is positive for JCV in the CSF. What is the mechanism of action of the disease-modifying therapy most likely to be attributed to this clinical scenario?

Which of the following is the mechanism of action of mitoxantrone?

Which of the following is the mechanism of action of riluzole?

A 40-year-old male presents to the clinic with difficulty swallowing. On additional questioning, he reports difficulty walking, falls, and dysarthria. Examination shows bilateral facial weakness, fasciculations, and gynecomastia. A CAG trinucleotide repeat on which of the following genes is the cause of this disease?

Which of the following medications are known to develop neutralizing antibodies (NAbs) against it with chronic use?

A 56-year-old female with a past medical history of IgA deficiency presents to the emergency room with a 4-day history of progressive, ascending lower extremity weakness. Neurological examination reveals flaccid paralysis of the bilateral lower extremities and areflexia. Imaging of the lumbar spine shows contrast enhancement of the cauda equina and CSF studies show elevated proteins and a normal WBC count. What is the most appropriate next step in therapy?

A 45-year-old female with a recent diagnosis of multiple sclerosis, based on MRI and CSF analysis, is referred to your clinic to discuss possible disease-modifying therapies. You review the clinical history with her and she states that for the past 18 months she has experienced progressive right upper and lower extremity weakness. She denies any periods of transient improvement or dramatic worsening of symptoms. Based on this clinical history, what is the most appropriate disease-modifying therapy for this patient?

This brain biopsy is consistent with which of the following pathologies?