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What is the state of the patient in the EEG shown below?
You are caring for a 19-year-old male in the neurocritical care unit after drowning. His brain MRI is pending clinical stability. Which finding on brain MRI is most likely after a severe global hypoxic injury?
Metachromatic leukodystrophy is due to a deficiency of which of the following enzymes?
A 45-year-old female presents as a trauma for an unhelmeted motorcycle accident. She has sustained significant blunt head trauma, and CTH shows hydrocephalus caused by edematous mass effect compressing the fourth ventricle. Which of the following shows the correct directional flow of CSF in a normal individual?
Alemtuzumab is a monoclonal antibody therapy that targets which of the following proteins?
A 7-day-old infant is in the hospital since birth when he starts having seizures. He has been feeding poorly thus far. On examination, he has hypotonia, as well as distinctive facial features of midface hypoplasia, hypoplastic supraorbital ridges, and a prominent high forehead. The metabolic testing panel returns with elevated very-long-chain fatty acids. What is the physiology of this disorder?
Which of the following medications used in the management of multiple sclerosis is the most teratogenic?
A 15-day-old female is evaluated in the NICU after being born to a G2P2 mother. On exam, the infant is jaundiced. Abdominal ultrasound shows severe hepatosplenomegaly. CT scan of the head shows hydrocephalus and periventricular calcifications, and a fundoscopic exam shows bilateral chorioretinitis. Serological testing is most likely to show infection with which organism?
The pathologic findings appreciated on this slide are secondary to which of the following pathologies?
What anatomical structure is the most common location for a Mycobacterium tuberculosis-related CNS infection?
A patient with relapsing-remitting multiple sclerosis presents to the emergency department with a new headache, confusion, and vision loss. A T2 sequence from their MRI is shown below. Lumbar puncture is positive for JCV in the CSF. What is the mechanism of action of the disease-modifying therapy most likely to be attributed to this clinical scenario?
A patient with a clinical history concerning for hydrocephalus has an MRI brain completed (see below). Surgical resection was completed and genetic analysis revealed no presence of an IDH mutation or 1p/19q co-deletion. What is the most likely diagnosis?
Which of the findings are most likely to be found on examination in a patient with the lesion appreciated in the image below?
A pediatric neurology consult was placed for a 5-day-old, full-term newborn with macrocephaly. When formally measured his head circumference was 46 cm. A tense fontanelle was appreciated on examination. A bedside ultrasound was performed and the only abnormality appreciated was significant hydrocephalus. What is the most likely etiology of the patient’s symptoms?
A 56-year-old woman with a history of right temporal epilepsy with no other comorbidities had an ambulatory 24-hour EEG performed. What is the state of the patient in this segment of the recording?